β-Nicotinamide Mononucleotide

As a cutting-edge ingredient in the realm of nutritional supplements, Bicells' β-Nicotinamide Mononucleotide (NMN) stands out for its potential role in supporting cellular energy production and overall health. NMN is a nucleotide that is naturally found in certain foods and is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme essential for various cellular functions. Our NMN is produced under strictly controlled conditions, adhering to GMP standards, and is backed by a comprehensive quality management system certified by ISO 9001 and FSSC22000. This ensures that our NMN is of the highest purity and is safe for consumption. It is an ingredient that is particularly valuable for dietary supplements aimed at promoting energy metabolism and potentially supporting healthy aging.

β-Nicotinamide Mononucleotide (NMN) is a naturally occurring nucleotide derivative of vitamin B₃ (niacin) and a critical precursor to nicotinamide adenine dinucleotide (NAD⁺), an essential coenzyme in cellular metabolism. Discovered in 2004, NMN gained prominence in 2013 when research demonstrated its potential to reverse age-related decline in mice. As a key NAD⁺ intermediate, NMN is pivotal in energy production, DNA repair, and mitochondrial function. Its ability to boost NAD⁺ levels—which decline significantly with age—has positioned NMN as a promising anti-aging and metabolic health compound.

Chemical Properties

Biological Functions and Mechanisms

1. NAD⁺ Biosynthesis

NMN is synthesized from nicotinamide (NAM) and 5-phosphoribosyl-1-pyrophosphate (PRPP) via the enzyme nicotinamide phosphoribosyltransferase (NAMPT). It is then converted to NAD⁺ by NMN adenylyltransferase (NMNAT). NAD⁺ serves as a co-substrate for:

• Sirtuins (SIRT1–7): Regulate DNA repair, inflammation, and metabolism

• PARP enzymes: Facilitate DNA damage repair

2. Anti-Aging and Metabolic Effects

• Mitochondrial Enhancement: Restores NAD⁺-dependent mitochondrial function

• DNA Repair: Activates SIRT1 to promote DNA damage repair

• Metabolic Regulation:

• Improves insulin sensitivity

• Reduces triglycerides and arterial stiffness

3. Other Physiological Roles

• Cardioprotection: Mitigates heart injury

• Reproductive Health: Improves ovarian function

• Inflammation Control: Suppresses inflammatory cytokines

Clinical Evidence in Humans

Sources and Production

Natural Sources

Industrial Synthesis

1. Microbial Fermentation: Primary commercial production method

2. Chemical Synthesis: Multi-step synthesis from niacin derivatives

3. Enzymatic Catalysis: Uses purified enzymes for high purity

Regulatory Status

Safety and Precautions

• Contraindications:

• Pregnancy/Lactation: Insufficient safety data

• Children: Not studied in individuals <18 years

• Cancer patients: Theoretical metabolic concerns

• Drug Interactions: May enhance effects of hypoglycemic medications